CORDIS Project
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This project investigates the NLRC4 inflammasome's role in autoinflammatory diseases, particularly focusing on mutations that lead to severe inflammation in infants. By studying knock-in and mutant mice, the research aims to clarify the mechanisms behind NLRC4-related conditions and improve treatment strategies.
Our immune system provides a protective mechanism to control and eliminate elements from pathogenic microbes and toxic substances.
Upon bacterial infection, our innate immune system initiates a pro-inflammatory response by activating the ""inflammasomes"".
These multiprotein platforms activate caspase-1 to produce proinflammatory cytokines.
An array of highly regulated inflammasome-mediated signalling pathways are identified.
When the signalling pathway is hyperactivated, overproduction of the d…
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