CORDIS Project
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This project investigates how mechanical forces affect the structure of viral and bacterial anchoring proteins. By using advanced techniques, it aims to understand their role in infection processes and identify molecules that could prevent infections.
Viruses and bacteria utilize proteins to attach and infect cells and tissues.
Viruses have envoloped proteins that especifically recongnize receptors in the surface of the target cells. HIV-1 recognices receptor CD4 in the surface of T cell throghout its envolope glycoprotein gp120.
In the case of bacteria, they attach to tissues using long filament called pilus.
Bacterial pilus type 1 is composed of several protein subunit arranged in chain, FimA-FimG-FimG-FimH.
The more external domain, FimH,…
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