CORDIS Project
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The incPRINT-DRUG project aims to develop a technology for identifying small molecules that can selectively target RNA-protein interactions, which are crucial in various diseases. By adapting high-throughput methods for drug testing in living cells, the project seeks to overcome challenges in RNA-targeted drug discover…
RNA transcripts have emerged as key regulators of diverse biological phenomena and are implicated in many human diseases including neurodegenerative disorders, cancers, viral infections and antibiotic resistance.
As such, RNA represents an untapped source of therapeutic targets.
Bioavailable small molecules have been recently successfully applied to target RNA.
One caveat, however, is that lead compounds are not easily designed from RNA sequence or structure and therefore targeting RNA by small…
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