CORDIS Project
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This project investigates the ACB1801 molecule's ability to restore major histocompatibility complex class I expression in tumor cells, aiming to enhance anti-tumor immunity. It combines dendritic cell vaccination with immune checkpoint blockade to improve cancer treatment efficacy.
One of the major mechanisms by which solid tumors escape anti-tumor immunity is the downregulation of major histocompatibility complex class I (MHC-I), which causes a failure in the recognition of tumor cells by the cytotoxicity T-cells.
The project proposed by Dr.
Teresa Ramos contains basic and translational aspects.
The basic aspect relies on investigating the mechanisms of action of the ACB1801 molecule (harmine), reported by the host team to restore the MHC-I in tumor cells, using state-of-…
LUXEMBOURG INSTITUTE OF HEALTH
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