CORDIS Project
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This project investigates the dynamics of DNA repair, specifically focusing on the search for homologous DNA during homologous recombination. It utilizes advanced techniques to visualize this process in yeast and aims to adapt the methods for mammalian cells.
Double-strand breaks (DSB) constantly challenge the integrity of the cellular genome and are important contributors to cancer and genetic diseases.
Repair of damaged DNA is a dynamic process that requires careful orchestration of a multitude of enzymes and chromatin constituents that are organized into centers (foci).
The outgoing laboratory recently developed powerful methods to explore the dynamics of focus assembly/disassembly in vivo.
Using these techniques, I will explore one of the most in…
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