CORDIS Project
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This project aims to understand the mechanisms of DNA replication, focusing on how the replication machinery interacts with chromatin. It seeks to clarify the processes involved in genome duplication and the challenges posed by nucleosome stability.
DNA replication, the process where the genetic material is duplicated, is one of the most important and basic processes a cell undertakes.
It is essential that this process is tightly and carefully regulated as errors in DNA replication are catastrophic, resulting in diseases like cancer.
The synthetic or S phase of the eukaryotic cell cycle is entirely devoted to genome duplication by orchestrating two processes:
DNA replication and histone production.
Histones are small basic proteins that tog…
THE FRANCIS CRICK INSTITUTE LIMITED
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