CORDIS Project
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This research focuses on the migration of smooth muscle cells in atherosclerosis and their pro-inflammatory properties. By analyzing human tissue samples, the project aims to uncover the molecular triggers of inflammation that contribute to plaque formation.
A critical event in the formation of mature atherosclerotic plaque is migration of smooth muscle cells (SMCs) from the media to the intima, where they produce extra-cellular matrix (ECM) proteins, forming a fibrous cap above the pro-inflammatory and lipid core. SMC are highly plastic, and can alter their state of differentiation in response to environmental cues.
Intimal SMC display pro-inflammatory properties, in that expression of the adhesion molecule P-selectin and cytokines are up-regulated…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom, LONDON
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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