CORDIS Project
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This project investigates the immune response to mesenchymal stem cells in mouse models, focusing on their behavior in autoimmune conditions. It aims to understand how these cells can be used therapeutically by assessing their immunogenicity and potential for tissue repair.
The immunogenicity of allogeneic mesenchymal stem cells (MSC) and their differentiated progeny in vivo under regular or inflammatory conditions will be addressed using established mouse models of allorecognition and spontaneous autoimmune diabetes.
Survival and homing of MSC in vivo in syngeneic and allogeneic recipients will be investigated by tracking MSC.
Allorecognition of mouse MSC in vivo will be assessed using CD8+ T cells from BM3 T cell receptor transgenic mice, which specifically recog…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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