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The IMPRINT project investigates how early-life gut microbiota influences the immune system and susceptibility to infections in adulthood. By studying mice, it aims to understand the role of specific bacteria and metabolites in regulating immune responses during weaning, particularly in relation to infections caused by…
Humans acquire a complex community of intestinal microorganisms in early life (gut microbiota), which helps development of the immune system, and which may reduce risk of inflammatory disease.
However, these complex microbiota-immune interactions in early life are underexplored and their subsequent influence on susceptibility to infection remains unknown.
The Eberl lab recently reported that a temporary intestinal inflammatory state, termed the ‘weaning reaction’, occurs in mice during a specifi…
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