CORDIS Project
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This project investigates the mechanisms behind trinucleotide repeat instability in neurological diseases using transgenic mice. It focuses on the role of chromatin environment and DNA mismatch repair proteins in repeat expansion and contraction, aiming to uncover therapeutic strategies to mitigate disease progression…
Since the identification of unstable trinucleotide repeats (TNRs) as the genetic cause of human neurological diseases, many studies have tried to unravel the mechanisms of repeat expansion. MSH2 and MSH3, DNA mismatch repair proteins, modify expansion in transgenic mice.
Circumstantial evidence suggests that cis-elements surrounding the repeats modulate their instability.
However, a detailed analysis of the relationship between chromatin environment and trinucleotide repeat instability is lackin…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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