CORDIS Project
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This project investigates how neutrophils, a type of immune cell, identify and eliminate necrotic DNA debris, which can contribute to inflammatory diseases. By understanding the mechanisms involved, the research aims to inform the development of new therapies for conditions linked to improper cellular debris removal.
Cell death is inherently connected to the existence of multicellular organisms.
Our body loses billions of cells a day due to thermal, mechanical or chemical damage in a cell death process with loss of plasma membrane integrity and pro-inflammatory properties known as necrosis.
Organisms face necrosis frequently, thus, there must be specific pathways to remove the large amount of cellular debris left behind.
In this way, it is no surprise that improper removal of cellular debris, such as DNA, is…
KATHOLIEKE UNIVERSITEIT LEUVEN
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