CORDIS Project
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This project explores the role of pyruvate transport in cancer metabolism, particularly how alterations in the mitochondrial pyruvate carrier may contribute to the Warburg effect. It aims to identify potential therapeutic targets by understanding these metabolic changes in cancer cells.
The role of metabolism in cancer has attracted massive attention in recent years.
Several studies highlighted the relevance of aberrant metabolic activities in a number of malignancies. A key node of eukaryotic metabolism is the transport of pyruvate between cytoplasm and mitochondria.
Pyruvate, the end product of glycolysis, plays an essential role in cellular metabolism as after transport into mitochondria it can be oxidized into acetyl-CoA, and further oxidized in the tricarboxylic acid cycle…
UNIVERSITE DE GENEVE
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