CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project investigates the potential of using heme to induce the oligomerization of antibodies for enhanced cancer therapy. By leveraging the interaction between heme and antibodies, the aim is to improve the immune response against tumors, leading to more effective cancer treatments.
The principal goal of this proof-of-concept study is to explore the feasibility of a cofactor-induced oligomerisation of IgG to potentiate the therapeutic efficacy of anti-cancer antibodies targeting the tumour site.
Our idea is based on two phenomena:
Firstly, in our previous studies on the interaction of heme with therapeutic antibodies we found that the interaction of Trastuzumab with heme results in the formation of well-organized oligomers through Fab-Fab interactions of two IgG molecules.…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
