CORDIS Project
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IMPACT investigates the role of a microbial metabolite in promoting fibrosis associated with heart failure and liver disease. It aims to uncover the mechanisms linking this metabolite to disease progression and explore potential therapeutic targets.
Fibrosis is a pathological feature caused by excessive extracellular matrix secretion, resulting in scar tissue that causes thickening and loss of tissue mobility, culminating in impaired organ function.
It is a common feature of heart failure and non-alcoholic steatohepatitis and an important determinant of morbidity and mortality.
However, relatively little is known about the underlying aetiology.
We and others have mapped alterations in the gut microbiota in different cardiometabolic disease…
UGOT - GOETEBORGS UNIVERSITET/UNIVERSITY OF GOTHENBURG
GOETEBORGS UNIVERSITET
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