CORDIS Project
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This project investigates the role of the cytokine oncostatin-M in the development of intestinal fibrosis associated with inflammatory bowel disease. By exploring immune-stromal interactions, it aims to uncover mechanisms of tissue repair and identify potential biomarkers for fibrosis, paving the way for new therapeuti…
Intestinal fibrosis is a common and serious complication of inflammatory bowel disease (IBD).
While intestinal inflammation can be treated pharmacologically based on our current understanding of the underlying pathogenesis, little is known about the mechanisms driving fibrogenesis.
Thus no approved therapies exist for intestinal fibrosis.
While stromal cells lie at the heart of fibrogenesis, our knowledge of how immune-derived signals instruct aberrant tissue repair and fibrosis is limited.
We r…
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