CORDIS Project
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This project focuses on improving gene manipulation efficiency in human hematopoietic stem cells by identifying antiviral factors that hinder gene transfer. It aims to enhance gene therapy techniques for treating various disorders by understanding the interactions between stem cells and viral vectors.
The low gene manipulation efficiency of human hematopoietic stem cells (HSC) remains a major hurdle for sustainable and broad clinical application of innovative therapies for a wide range of disorders.
Indeed, high vector doses and prolonged ex vivo culture are still required for clinically relevant levels of gene transfer even with the most established lentiviral vector-based delivery platforms.
Current and emerging gene transfer and editing technologies expose HSC to components potentially rec…
UNIVERSITA DEGLI STUDI DI PAVIA
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Italy, Milano
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: No
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