CORDIS Project
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This project investigates how metastatic cancer cells evade immune responses, particularly from natural killer cells. By using a molecular barcoding technique, it aims to identify new immune evasion mechanisms and enhance immunotherapy strategies for cancer patients.
Most cancer patients are resistant to immunotherapies, especially patients with liver and bone metastases.
This suggests that during metastasis, cells acquire additional immune evasion mechanisms that dictate susceptibility to immunotherapies.
Current immunotherapies initiate T cell-mediated killing of cancer cells.
However, combining them with agents that target other immune cells in the body, such as natural killer (NK) cells, may be more effective.
Whether immune evasion mechanisms of metasta…
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