CORDIS Project
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This project aims to elucidate the mechanisms of the adaptive immune system, focusing on how antigenic peptides are processed and recognized by T cells. It seeks to uncover the complex interactions within the peptide-loading complex and their implications for immune responses.
To combat daily threats of pathogens and abnormal cells, the human organism features a sophisticated defense mechanism called the adaptive immune system.
In broad terms, this intricate mechanism is triggered by specific peptide epitopes presented on molecules of the major histocompatibility complex class I (MHC I), which are scanned by cytotoxic T cells.
Intracellular transport, loading, and cell-surface recognition of antigenic peptides on MHC I are orchestrated by machineries, the peptide-load…
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
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