CORDIS Project
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This project investigates the role of bile acids in regulating metabolism and immune function, particularly in obesity and type 2 diabetes. It aims to explore how bile acids influence immune cell activity and their potential therapeutic implications.
The role of chronic inflammation in obesity, metabolic and cardiovascular diseases is increasingly recognized.
Bile acids (BA), synthesized in the liver and modified by the gut flora, facilitate lipid absorption in the intestine. BA modulate lipid and glucose homeostasis by activating the nuclear receptor FXR and the GPCR TGR5.
Intriguingly, peripheral BA concentrations are elevated in type 2 diabetes (T2D) and FXR mediates the beneficial metabolic response to gastric bypass in mice.
The immune…
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