CORDIS Project
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This project investigates the role of the enzyme histone deacetylase 6 in regulating mitochondrial dynamics and immune responses in macrophages. It aims to clarify the mechanisms by which HDAC6 influences antibacterial functions and identify new pathways and substrates involved in inflammation.
Macrophages are key cellular components of innate immunity.
During inflammation, they respond to danger signals by inducing gene expression or altering pre-existing proteins.
One such post-translational modification is carried out by histone deacetylases, enzymes that remove acetyl groups from lysine. HDAC6 is a unique member of this family due to its cytoplasmic localisation and its structure (two catalytic domains and one zinc finger ubiquitin binding domain).
Several targets of HDAC6 have bee…
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
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