CORDIS Project
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This project investigates how the E3 ubiquitin ligase Listerin influences the presentation of peptides on MHC-I complexes. By exploring its role in antigen presentation, the research aims to enhance understanding of immune responses.
Mammalian cells present a fingerprint of their proteome through the display of endogenous peptides on MHC-I complexes.
This allows for CD8+ T cells to recognize and kill cells infected with viruses or other intracellular parasites, or cells accumulating aberrant proteins resulting from malignant transformation.
The MHC-I peptides originate from protein degradation by the ubiquitin proteasome system, which is responsible for controlled protein turnover.
This would mean that viral proteins, which…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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