CORDIS Project
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This project investigates the role of a specific receptor in Alzheimer's disease by examining how inhibiting this receptor affects cognitive decline and brain inflammation in a mouse model. It aims to uncover potential therapeutic strategies to restore brain function in Alzheimer's patients.
Background and rationale:
Alzheimer's disease (AD) is the main cause of dementia, with substantial socio-economic burdens.
Due to the absence of a cure, understanding disease mechanisms and developing new therapies is crucial.
Age-related systemic and brain inflammation contributes to cognitive decline.
Inhibiting prostaglandin 2 (PGE2) - PGE2 receptor 2 (EP2) signalling has restored youthful hippocampal functions in ageing mice, but its specific impact on AD-related deficits remains unclear.
Ai…
UNIVERSITE DU LUXEMBOURG
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United States, Stanford
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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