CORDIS Project
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This project focuses on understanding and manipulating the immune system to address issues like autoimmunity and cancer. It combines mouse model research with human studies to discover disease-related genes and develop personalized medicine strategies through functional genomics.
Control over the activation of the immune system is central to the key issues of human health.
Autoimmunity, atopy, persistent infections and tumours all share a common root cause in a sub-optimal balance between immune activity and tolerance.
At the heart of this balance are T cells, with the capacity for both activation and suppression.
Research in mouse models has allowed enormous progress to be made on understanding fundamental mechanics, and yet the next step translating this understandin…
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