CORDIS Project
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This project investigates the complex cellular environment of mouse bone marrow to understand how different cell types influence blood cell development and the progression of blood cancers. By using advanced techniques, it aims to identify microenvironmental factors that affect hematopoietic cell fate and explore poten…
The complex architecture of the mammalian hematopoietic system has been studied for decades, yet the molecular mechanisms underlying cell fate commitment remain poorly understood.
Although cytokine signals are major determinants of hematopoietic cell fate, only few niches of stem and progenitor cells have been characterized.
Here, we propose to resolve the cell type composition of mouse bone marrow by integrating single-cell RNA-seq with high-resolution spatial analysis of gene expression in tis…
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
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