CORDIS Project
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This project aims to explore the immune landscape in prostate cancer to develop new treatments that combine pro-senescence therapies with immunotherapy. It investigates how immune cells interact with senescent tumor cells to enhance cancer treatment efficacy.
We have previously demonstrated that cellular senescence opposes tumorigenesis thereby opening up new potential opportunities for cancer treatment.
Senescence and tumor immunity in cancer are tightly interconnected.
Tumor-infiltrating immune cells promote the clearance of senescent tumor cells thereby contributing to the tumor suppressive function of senescence.
Moreover, T lymphocytes can drive senescence in cancers by secreting different cytokines in the tumor microenvironment.
We have also re…
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