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The ImmuBRAIN project investigates the interplay between adaptive and innate immune responses in autoimmune encephalitides, particularly focusing on N-Methyl-D-Aspartate receptor encephalitis. It employs advanced antibody profiling and experimental models to understand how immune mechanisms contribute to neuronal dysfu…
Autoimmune encephalitides (AE) are severe brain disorders mediated by antibodies against neuronal proteins, such as the N-Methyl-D-Aspartate receptor (NMDAR).
The antibody effects are reversible, explaining recovery after antibody-depleting therapies.
However, it is unknown why many patients have incomplete recovery and persistent deficits.
In these cases, additional immune mechanisms might be at play.The objective of ImmuBRAIN is to define how the adaptive immune response (autoantibodies) cross…
FUNDACIO DE RECERCA CLINIC BARCELONA-INSTITUT D INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
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