CORDIS Project
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This research aims to identify how environmental factors interact with genetic variants linked to immune-mediated diseases. By analyzing single-cell RNA sequencing data, it seeks to uncover the molecular pathways influenced by these interactions.
In the last few years genome-wide association studies have revealed thousands of genetic variants associated to immune-mediated diseases, such as rheumatoid arthritis and Crohn's disease.
Although it is evident that non-genetic factors can also trigger these diseases, presumably by interacting with the risk SNPs, we do not know what these factors are or how they affect risk-SNPs.I hypothesize that environmental factors that increase disease risk also mediate the downstream molecular effects of d…
UNIVERSITAIR MEDISCH CENTRUM GRONINGEN
ACADEMISCH ZIEKENHUIS GRONINGEN
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