CORDIS Project
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The IMMAc project investigates how the melanocortin 3 receptor influences muscle mass regulation in response to nutrients. It aims to understand the receptor's role in muscle maintenance and its potential therapeutic applications for muscle wasting conditions.
We are yet to understand how the body regulates muscle mass in response to nutrient sensing at a whole organism level.
The loss of muscle mass occurs in a range of diseases, including cancer cachexia, in which mortality risk is substantially increased by muscle wasting.
The melanocortin signalling system in the hypothalamus is a crucial node in energy and nutrient sensing, with growing evidence implicating the understudied melanocortin 3 receptor (MC3R) in the control of body composition and lea…
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