CORDIS Project
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This project focuses on understanding the role of a specific mutation in the PLCG2 gene related to Alzheimer's disease. It aims to characterize this mutation in human microglia to identify potential therapeutic targets for the disease.
Alzheimer’s disease (AD) is an irreversible neurodegenerative condition affecting 50 million people worldwide.
To date, no disease modifying therapy for AD is available.
Neuroinflammation is emerging as an important component of the disease. A recent GWAS analysis identified a rare protective coding mutation (P522A) in the PLCG2 (Phospholipase C Gamma 2) gene that is associated with AD.
Interestingly, the gene encodes a transmembrane signaling enzyme that is highly enriched in microglia.
The maj…
UNIVERSITA DEGLI STUDI GABRIELE D'ANNUNZIO DI CHIETI-PESCARA
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LOS ANGELES UCLA SANTA BARBARA UCSB DAVIS UCD RIVERSIDE UCR SAN DIEGO UCSD SANTA CRUZ UCSC IRVIN
United States, Berkeley
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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