CORDIS Project
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This project focuses on developing a model for the antigen processing and presentation pathway, which is crucial for understanding how the immune system activates cytotoxic T cells. It combines mechanistic modeling with machine learning to improve epitope prediction for therapeutic applications.
The immune system can patrol cell status by recognising epitopes bound to Human Leukocyte Antigen class I (HLA-I) molecules and triggering cytotoxic T cell (CTL) activation.
Epitopes arrive at the cell surface through several steps of the antigen processing and presentation pathway (APP).
Despite major discoveries in the past decades, the precise dynamics of APP are still not fully understood.
These dynamics, however, determine the types and quantities of epitopes and therefore regulate the CTL…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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