CORDIS Project
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This project investigates the relationship between p53 mutations in cancer and tumor blood vessel characteristics. By using advanced imaging techniques, it aims to develop a non-invasive method to determine p53 mutation status, potentially guiding personalized cancer treatments.
The p53 protein is mutated in over 50% of cancers.
Because its expression often promotes tumor growth and is associated with resistance to treatment, there has been great interest in treating cancers based on p53 mutation status.
However, the use of p53- targeted therapies requires knowing the mutation status. DNA sequencing is one approach, but requires invasive biopsies, and newer sequencing techniques still face technical hurdles.
Non-invasive imaging techniques offer an alternative approach…
KAROLINSKA INSTITUTET
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