CORDIS Project
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This project investigates the diversity of endothelial cells (EC) in blood and lymphatic vessels, focusing on both intrinsic and extrinsic factors. By integrating in vitro and in vivo approaches, it aims to develop tailored therapies for vascular disorders through a better understanding of EC characteristics and behavi…
Endothelial cells (EC) lining the inside of blood/lymphatic vessels in different organs show significant heterogeneity caused by cell-intrinsic and -extrinsic factors.
While intrinsic properties are preserved in vitro, EC-extrinsic characteristics are lost upon isolation from the in vivo context.
Thus, getting a grasp on EC diversity requires an approach that integrates EC-intrinsic and -extrinsic cues. EC heterogeneity likely forms the basis of vessel-type restricted disorders and may explain t…
KATHOLIEKE UNIVERSITEIT LEUVEN
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