CORDIS Project
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The ImAgine project explores the relationship between innate immune signaling and aging processes, focusing on the cGAS-STING pathway. It aims to understand how this pathway contributes to age-related changes and the body's response to infections, potentially leading to new treatment strategies for age-associated disea…
The innate immune system has evolved signalling receptors, which detect various stresses including microbial infection but also signals emanating from non-infectious cellular damage.
Upon activation, these signalling receptors can trigger a variety of distinct effector responses collectively aimed towards maintaining the integrity of the host.
The recognition of cytosolic DNA through the cGAS-STING pathway is a fundamental mechanism through which pathogens and cellular stress evoke an inflammato…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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