CORDIS Project
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This project investigates the conversion of glial cells into neurons in the brain, focusing on a specific type of interneuron that is crucial for brain function. It aims to visualize this transformation in real time and assess how these new neurons integrate into existing brain circuits, potentially offering insights f…
Direct lineage reprogramming of cell identity in the nervous system offers the prospect of remodelling diseased brain circuits.
Recent years have provided evidence for the possibility of converting brain glia into neurons in vivo.
Yet, the process by which glial cells give up their original identity and adopt a neuronal fate remains by large enigmatic.
Moreover, it is unclear how neurons induced from glia may integrate into the pre-existing circuits of non-neurogenic brain regions such as the ce…
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