CORDIS Project
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This project investigates the mechanisms behind invasive mold infections, focusing on how molds evade immune responses by disrupting iron regulation in macrophages. It aims to identify key iron transporters and regulatory genes to inform better therapeutic strategies against respiratory diseases caused by molds.
Airborne filamentous fungi (molds) are major causes of respiratory diseases in an expanding population of patients with complex immune and metabolic defects.
Invasive mold infections (IMI) are associated with substantial mortality and enormous economic impact.
Understanding pathogenesis of IMI is an unmet need for design of better therapies.
We have put forward a novel mechanism for the pathogenesis of IMI, according to which development of IMI requires two discrete mechanisms (a) phagosome matu…
FOUNDATION FOR RESEARCH AND TECHNOLOGYHELLAS
IDRYMA TECHNOLOGIAS KAI EREVNAS
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