CORDIS Project
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This project investigates the inheritance and maintenance of mitochondrial DNA, which is crucial for energy production in cells. By using advanced imaging techniques, the research aims to uncover the mechanisms that ensure the integrity and distribution of mitochondrial DNA, with implications for understanding age-rela…
Essential subunits of the mitochondrial respiratory chain, which generates the majority of energy in eukaryotic cells, are encoded in the mitochondrial genome (mtDNA) that is present in hundreds of copies in every cell.
Mutations within mtDNA have been identified as the cause for a multitude of human diseases and have been tightly linked to the ageing process and altered stem cell homeostasis.
Accordingly, to ensure organismal health, good copies of mtDNA have to be faithfully inherited during c…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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