CORDIS Project
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This project investigates how intestinal epithelial cells respond to viral infections, focusing on the balance between recognizing pathogens and tolerating beneficial microbes. By exploring signaling pathways and cellular mechanisms, the research aims to enhance understanding of immune responses in the gut.
Intestinal epithelial cells (IECs) constitute the primary barrier that enteric pathogens have to face.
The mechanism by which innate immunity is regulated in IECs remains unclear.
However, it is known that a delicate balance is required to efficiently recognize pathogens and at the same time to not illicit an immune response against the commensal microbial flora.
Inappropriate immune response to the commensal flora is suspected to be responsible for inflammatory bowel diseases.We found that IECs…
UNIVERSITATSKLINIKUM HEIDELBERG
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