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The IGpath project aims to understand the role of B cell receptors in the development of certain blood cancers, particularly B cell non-Hodgkin lymphomas. It combines various methodologies to uncover mechanisms that could lead to new treatments and biomarkers.
The B cell receptor immunoglobulin (BcR IG) is important for the ontogeny and evolution of malignancies of mature B cells (B cell non-Hodgkin lymphomas, B-NHLs), mediating critical interactions with the microenvironment, including recognition of and selection/activation by antigens.
Of note, inhibition of BcR IG-mediated signaling has emerged as a highly efficacious treatment mode for these tumors, highlighting their dependence on extrinsic triggering.
Nevertheless, open issues abound regarding…
CENTRE FOR RESEARCH AND TECHNOLOGY HELLAS CERTH
ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS
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