CORDIS Project
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This project investigates how cancer cells adapt their division process under physical constraints. By examining the role of Ras-ERK signaling in mitotic rounding, it aims to identify mechanisms that allow cancer cells to divide effectively in challenging environments.
Mammalian cells must round up to divide by remodeling their adhesions and their cytoskeleton to form a stiff actin cortex.
Mitotic rounding provides the space necessary to develop a mitotic spindle to undergo symmetric chromosomal segregation.
If mitotic rounding is impeded by physical confinement or preventing adhesion remodeling, defects in spindle assembly and chromosomal missegregation can lead to mitotic cell death.
In cancer, the cells must divide in a challenging environment which can alt…
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