CORDIS Project
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This project aims to characterize B cells related to pneumococcal immunity, focusing on their role in vaccine response. By analyzing various cellular markers, it seeks to improve vaccine efficacy against pneumococcal pneumonia in different populations.
Pneumococcal pneumonia is one of the leading causes of death in children and the elderly worldwide.
Pneumococcal vaccines have significantly reduced global incidence of pneumococcal disease, however, current vaccines show varying efficacy among covered serotypes, leading to insufficient level of protection for complete herd immunity.
Memory B cells (Bmem) are responsible for high-affinity and long-lasting humeral immunity, and serotype-specific Bmem are associated with increased protection again…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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