CORDIS Project
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This project focuses on understanding intrinsically disordered proteins and regions (IDPs/IDRs) in eukaryotic genomes. Using a high-throughput approach called IdrSeq, it aims to identify functional IDRs and the genes that regulate their roles in transcription, protein stability, and assembly, with potential application…
A large fraction of any eukaryotic genome (>40%) encodes protein segments that do not adopt a defined tertiary structure.
These proteins or regions are called intrinsically disordered proteins/regions (IDPs/IDRs). IDRs are enriched in critical functions such as transcription and signaling, and have been linked with numerous diseases including neurodegeneration and cancer.
In contrast to structured regions, the molecular principles behind the sequence-function relationship of IDRs remain poorly u…
UNITED KINGDOM RESEARCH AND INNOVATION
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