CORDIS Project
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This project aims to uncover the mechanisms by which cells restore epigenetic information after DNA replication. It introduces a new technology, Nascent Chromatin Capture, to study chromatin restoration processes and their implications for genome integrity and disease.
During lineage propagation, cells must duplicate their genetic and epigenetic information to maintain cell identity.
However, the mechanisms underlying the maintenance of epigenetic information in dividing cells remain largely unknown.In S phase, progression of DNA replication forks provokes a genome-wide disruption of the epigenetic information.
While nucleosomes are rapidly reassembled on newly replicated DNA, full restoration of epigenetic information is not completed until after mitosis.
Thi…
UNIVERSITY OF DUNDEE
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