CORDIS Project
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This project studies the Heat Shock Factor 1 in the nematode C. elegans, focusing on its role in longevity and protection against protein aggregation. The research aims to uncover molecular mechanisms that could lead to new therapies for neurodegenerative diseases.
The Heat shock Factor 1 (HSF-1) is a transcription factor that upon activation enters the nucleus and regulates the transcription of its target gene networks.
In the nematode C. elegans, HSF-1 is critical for the regulation of a variety of fundamental biological functions including development and stress resistance.
In addition, it mediates protection from toxic protein aggregation and longevity facilitated by reduction of the Insulin/IGF signaling pathway, functions that point to HSF-1 as a pro…
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