CORDIS Project
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This project develops a method for efficient genetic analysis in human cells using insertional mutagenesis. It aims to identify host factors involved in viral infections, such as Ebola and influenza, and create a comprehensive atlas of host factors for various viruses, enhancing our understanding of viral entry mechani…
The most powerful and direct way to get insight into complex biological systems is to remove individual components and observe the consequences.
Cultured human cells are widely used to model and study aspects of human disease.
Although human cells can be analyzed and manipulated in numerous ways, their genome has remained refractory to efficient mutagenesis-based analysis.We have developed an insertional mutagenesis-based approach in haploid and near-haploid human cells.
We have shown that this…
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
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