CORDIS Project
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This project investigates the genetic networks that determine limb identity in vertebrates, focusing on the transcription factor Pitx1. By using mouse models and advanced screening technologies, it aims to identify new genes involved in limb development, enhancing our understanding of how diverse limb structures are ge…
Vertebrates have two pairs homologous of appendages, the forelimbs and the hindlimbs.
Although these appendages are morphologically distinct, it appears that the genetic networks controlling their development act equivalently in both appendages.
While the mechanisms that initiate limb outgrowth and its polarity establishment are reasonably well understood, much less is known about genes regulating limb identity specification. A single gene, the transcription factor Pitx1, has been clearly demons…
MEDICAL RESEARCH COUNCIL
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