CORDIS Project
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This project investigates the role of specific proteins in the misfolding of tau, a protein linked to neurodegenerative diseases like Alzheimer’s. By using advanced biosensor assays and genetic screening, the goal is to identify targets that can modulate tau seeding, potentially leading to new therapeutic strategies to…
The microtubule-associated protein tau is the most commonly misfolded protein in neurodegenerative disorders including Alzheimer’s disease and other related tauopathies.
These neurological illnesses are hypothesized to share a common mechanism of disease progression, where pathogenic aggregates or ‘seeds’ of the tau protein function as templates promoting misfolding of functional, soluble tau protein.
Under this premise, therapeutic strategies that modulate the seeding cascade, have high potenti…
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
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