CORDIS Project
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This project aims to identify colon cancer stem cells using the Lgr5 gene as a marker. It involves analyzing Lgr5 expression in tumors, isolating Lgr5 positive cells, and comparing their genetic profiles with normal intestinal stem cells to uncover genes involved in malignant transformation.
In the murine small intestine, the epithelium renews every five days.
This vigorous self- renewing process is controlled by several secreted Wnt factors at the base of the crypt-villus axis.
Lgr5/Gpr49 gene is a Wnt target gene that displays a complex expression pattern during embryogenesis, yet expression in most tissues subsides around birth.
In adult mice, Lgr5 expression is restricted to rare, scattered cells in multiple tissues including the hair follicles, mammary glands and the intestinal…
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
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