CORDIS Project
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This fellowship aims to develop new chemical processes for creating reactive iminium ions from lactams and amides, facilitating carbon-carbon bond formation. The project explores innovative synthetic pathways to produce complex nitrogen-containing structures.
The aim of this fellowship is to develop new reductive cyclization cascades of lactams and amides that establish these feedstock chemicals as important chemical precursors to reactive iminium ions which can be intercepted by pendant nucleophiles and exploited in carbon-carbon bond formation.
A range of indole nucleophiles linked to amide and lactam functionality will be investigated for performance in the iridium catalyzed reductive cyclization cascades, and, based on successful proof of concept…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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