CORDIS Project
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This project investigates the role of mRNA methylation in the replication of Influenza A virus. By mapping methylation sites and assessing their impact on viral gene expression, it aims to uncover new mechanisms of viral pathogenesis.
It has recently become apparent that post-transcriptional editing of mRNA by methylation of adenosines (m6A) plays a key role in regulating gene expression.
In particular, total loss of m6A editing blocks the development of early embryos in a number of organisms.
However, how m6A modifications, which are added in the nucleus and primarily detected by 3 cytoplasmic “reader” proteins, exert their effects remains unknown.
The presence of m6A on viral transcripts has been known for 40 years, yet has…
INSTITUT PASTEUR
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United States, Durham Nc
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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