CORDIS Project
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This project aims to validate the effectiveness of ruthenium-based photoactivated chemotherapy compounds on cancer models with low oxygen levels. By activating the treatment with light, it targets tumors while minimizing damage to healthy tissue, offering a potential solution for hard-to-treat cancers.
In this Proof-of-Concept project I will show the commercial potential of ruthenium-based photoactivated chemotherapy (PACT) compounds developed in my ERC Starting Grant by demonstrating their efficacy on hypoxic cancer models.
Photoactivated chemotherapy is a new class of phototherapy to treat cancer.
In principle, PACT looks similar to photodynamic therapy (PDT): light irradiation of the tumour in vivo leads to local activation of the anticancer prodrug, thereby limiting the toxicity of the tr…
UNIVERSITEIT LEIDEN
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